Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM50032896
Substrate
n/a
Meas. Tech.
ChEMBL_1431799 (CHEMBL3385095)
EC50
651±n/a nM
Citation
 Abdel-Magid, AF Liver x receptor agonists for the treatment of coronary heart disease and other disorders. ACS Med Chem Lett 5:1186-7 (2014) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50032896
Synonyms:
CHEMBL3342786
Type:
Small organic molecule
Emp. Form.:
C27H21ClF3N5O2S
Mol. Mass.:
572.001
SMILES:
Cc1nc(cn1-c1ccc(cc1-n1nncc1Cc1cccc(Cl)c1)-c1cccc(c1)S(C)(=O)=O)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: