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Target
Reverse transcriptase
Ligand
BDBM50033878
Substrate
n/a
Meas. Tech.
ChEMBL_1435796 (CHEMBL3389551)
IC50
3.0±n/a nM
Citation
 Famiglini, V; La Regina, G; Coluccia, A; Pelliccia, S; Brancale, A; Maga, G; Crespan, E; Badia, R; Riveira-Muñoz, E; Esté, JA; Ferretti, R; Cirilli, R; Zamperini, C; Botta, M; Schols, D; Limongelli, V; Agostino, B; Novellino, E; Silvestri, R Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors. J Med Chem 57:9945-57 (2014) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50033878
Synonyms:
CHEMBL3358170
Type:
Small organic molecule
Emp. Form.:
C22H19ClN2O4S
Mol. Mass.:
442.915
SMILES:
Cc1cc(C)cc(c1)S(=O)(=O)c1c([nH]c2ccc(Cl)cc12)C(=O)NCc1ccco1
Structure:
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