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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50036664
Substrate
n/a
Meas. Tech.
ChEMBL_1433752 (CHEMBL3387010)
EC50
2.0±n/a nM
Citation
 Azimioara, M; Alper, P; Cow, C; Mutnick, D; Nikulin, V; Lelais, G; Mecom, J; McNeill, M; Michellys, PY; Wang, Z; Reding, E; Paliotti, M; Li, J; Bao, D; Zoll, J; Kim, Y; Zimmerman, M; Groessl, T; Tuntland, T; Joseph, SB; McNamara, P; Seidel, HM; Epple, R Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists. Bioorg Med Chem Lett 24:5478-83 (2015) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50036664
Synonyms:
CHEMBL3354795
Type:
Small organic molecule
Emp. Form.:
C27H25F4N5O2
Mol. Mass.:
527.5133
SMILES:
COCCN(C)C(=O)[C@@]1(Cc2cccc(F)c2)NCc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F |r|
Structure:
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