Reaction Details Report a problem with these data
Target
Glutathione S-transferase Mu 2
Ligand
BDBM50038315
Substrate
n/a
Meas. Tech.
ChEMBL_1441153 (CHEMBL3378817)
IC50
50±n/a nM
Citation
 Rotili, D; De Luca, A; Tarantino, D; Pezzola, S; Forgione, M; Morozzo Della Rocca, B; Falconi, M; Mai, A; Caccuri, AM Synthesis and structure--activity relationship of new cytotoxic agents targeting human glutathione-S-transferases. Eur J Med Chem 89:156-71 (2014) [PubMed]  Article 
Target
Name:
Glutathione S-transferase Mu 2
Synonyms:
GST class-mu 2 | GST4 | GSTM2 | GSTM2-2 | GSTM2_HUMAN | Glutathione S-transferase Mu 2
Type:
PROTEIN
Mol. Mass.:
25743.85
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1441153
Residue:
218
Sequence:
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
  
Inhibitor
Name:
BDBM50038315
Synonyms:
CHEMBL3360511
Type:
Small organic molecule
Emp. Form.:
C13H8N4O5S
Mol. Mass.:
332.291
SMILES:
ONC(=O)c1ccc(Sc2ccc([N+]([O-])=O)c3nonc23)cc1
Structure:
Search PDB for entries with ligand similarity: