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Target
Serine racemase
Ligand
BDBM14673
Substrate
n/a
Meas. Tech.
ChEMBL_1441161 (CHEMBL3378825)
IC50
67000±n/a nM
Citation
 Vorlová, B; Nachtigallová, D; Jirásková-Vanícková, J; Ajani, H; Jansa, P; Rezác, J; Fanfrlík, J; Otyepka, M; Hobza, P; Konvalinka, J; Lep?ík, M Malonate-based inhibitors of mammalian serine racemase: kinetic characterization and structure-based computational study. Eur J Med Chem 89:189-97 (2014) [PubMed]  Article 
Target
Name:
Serine racemase
Synonyms:
D-serine ammonia-lyase | D-serine dehydratase | L-serine ammonia-lyase | L-serine dehydratase | SRR_MOUSE | Srr
Type:
PROTEIN
Mol. Mass.:
36355.92
Organism:
Mus musculus
Description:
ChEMBL_1441161
Residue:
339
Sequence:
MCAQYCISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQRIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKLLIEPTAGVALAAVLSQHFQTVSPEVKNVCIVLSGGNVDLTSLNWVGQAERPAPYQTVSV
  
Inhibitor
Name:
BDBM14673
Synonyms:
Fragment 3 | Malonic Acid | propanedioic acid
Type:
Small organic molecule
Emp. Form.:
C3H4O4
Mol. Mass.:
104.0615
SMILES:
OC(=O)CC(O)=O
Structure:
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