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TargetLactate dehydrogenase A (LDHA)
LigandBDBM50040093
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1443550
IC50 360±n/a nM
Citation Fauber, BPDragovich, PSChen, JCorson, LBDing, CZEigenbrot, CLabadie, SMalek, SPeterson, DPurkey, HERobarge, KSideris, SUltsch, MWei, BYen, IYue, QZhou, A Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett24:5683-7 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lactate dehydrogenase A (LDHA)
Name:L-lactate dehydrogenase A chain
Synonyms:Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | Renal carcinoma antigen NY-REN-59
Type:Protein
Mol. Mass.:36694.85
Organism:Homo sapiens (Human)
Description:P00338::PDB Code: 4ajp
Residue:332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50040093
NameBDBM50040093
Synonyms:CHEMBL3359438
TypeSmall organic molecule
Emp. Form.C19H15ClO3S
Mol. Mass.358.839
SMILESOC1=C(Sc2ccccc2Cl)C(=O)OC2(CCc3ccccc23)C1 |c:1|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a