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Target
Cannabinoid receptor 1
Ligand
BDBM50041001
Substrate
n/a
Meas. Tech.
ChEMBL_1444771 (CHEMBL3378472)
EC50
59±n/a nM
Citation
 Han, S; Thoresen, L; Zhu, X; Narayanan, S; Jung, JK; Strah-Pleynet, S; Decaire, M; Choi, K; Xiong, Y; Yue, D; Semple, G; Thatte, J; Solomon, M; Fu, L; Whelan, K; Al-Shamma, H; Gatlin, J; Chen, R; Dang, H; Pride, C; Gaidarov, I; Unett, DJ; Behan, DP; Sadeque, A; Usmani, KA; Chen, C; Edwards, J; Morgan, M; Jones, RM Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists. Bioorg Med Chem Lett 25:322-6 (2014) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50041001
Synonyms:
CHEMBL3354942
Type:
Small organic molecule
Emp. Form.:
C23H21F2N3O
Mol. Mass.:
393.4291
SMILES:
[H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)c1ccccc1 |r|
Structure:
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