Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50041089
Substrate
n/a
Meas. Tech.
ChEMBL_1445728 (CHEMBL3374865)
Ki
98±n/a nM
Citation
 Kriegl, JM; Martyres, D; Grundl, MA; Anderskewitz, R; Dollinger, H; Rast, G; Schmid, B; Seither, P; Tautermann, CS Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: insights from a receptor model. Bioorg Med Chem Lett 25:229-35 (2014) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50041089
Synonyms:
CHEMBL3355963
Type:
Small organic molecule
Emp. Form.:
C32H35F2N3O2S
Mol. Mass.:
563.701
SMILES:
CCOC(=O)c1ccnc(c1)-n1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc12
Structure:
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