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Target
Probable C-C chemokine receptor type 3
Ligand
BDBM50041193
Substrate
n/a
Meas. Tech.
ChEMBL_1445729 (CHEMBL3374866)
Ki
72±n/a nM
Citation
 Kriegl, JM; Martyres, D; Grundl, MA; Anderskewitz, R; Dollinger, H; Rast, G; Schmid, B; Seither, P; Tautermann, CS Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: insights from a receptor model. Bioorg Med Chem Lett 25:229-35 (2014) [PubMed]  Article 
Target
Name:
Probable C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 | CC-CKR-3 | CCR-3 | CCR3_MOUSE | CD_antigen=CD193 | CKR3 | Ccr3 | Cmkbr1l2 | Cmkbr3 | MIP-1 alpha RL2 | Macrophage inflammatory protein 1-alpha receptor-like 2 | Probable C-C chemokine receptor type 3
Type:
PROTEIN
Mol. Mass.:
41791.57
Organism:
Mus musculus
Description:
ChEMBL_1445729
Residue:
359
Sequence:
MAFNTDEIKTVVESFETTPYEYEWAPPCEKVRIKELGSWLLPPLYSLVFIIGLLGNMMVVLILIKYRKLQIMTNIYLFNLAISDLLFLFTVPFWIHYVLWNEWGFGHYMCKMLSGFYYLALYSEIFFIILLTIDRYLAIVHAVFALRARTVTFATITSIITWGLAGLAALPEFIFHESQDSFGEFSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIRLIFVVMIVFFIFWTPYNLVLLFSAFHSTFLETSCQQSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKHLRLFFHRNVAVYLGKYIPFLPGEKMERTSSVSPSTGEQEISVVF
  
Inhibitor
Name:
BDBM50041193
Synonyms:
CHEMBL3355954
Type:
Small organic molecule
Emp. Form.:
C31H32F2N6S
Mol. Mass.:
558.688
SMILES:
CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(cc1)-c1nnn[nH]1
Structure:
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