Target
Sphingosine 1-phosphate receptor 4
Ligand
BDBM50041983
Substrate
n/a
Meas. Tech.
ChEMBL_1443671 (CHEMBL3380144)
EC50
85±n/a nM
Citation
 Buzard, DJLopez, LMoody, JKawasaki, ASchrader, TOKasem, MJohnson, BZhu, XThoresen, LKim, SHGharbaoui, TSengupta, DCalvano, LKrishnan, AGao, YSemple, GEdwards, JBarden, JMorgan, MUsmani, KChen, CSadeque, AChen, WChristopher, RJThatte, JFu, LSolomon, MWhelan, KAl-Shamma, HGatlin, JGaidarov, IAnthony, TLe, MUnett, DJStirn, SBlackburn, ABehan, DPJones, RM (7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists. ACS Med Chem Lett 5:1334-9 (2014) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 4
Synonyms:
EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41647.39
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
  
Inhibitor
Name:
BDBM50041983
Synonyms:
CHEMBL3359523
Type:
Small organic molecule
Emp. Form.:
C24H23ClF3NO4
Mol. Mass.:
481.892
SMILES:
CC(C)Oc1ccc(COc2ccc3n4CC[C@H](CC(O)=O)c4c(Cl)c3c2)cc1C(F)(F)F |r|
Structure:
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