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TargetDual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
LigandBDBM50042034
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1443870
IC50 1300±n/a nM
Citation Sogabe, YMatsumoto, THashimoto, TKirii, YSawa, MKinoshita, T 5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner. Bioorg Med Chem Lett25:593-6 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Name:Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Synonyms:Dual specificity mitogen-activated protein kinase kinase 7
Type:Protein
Mol. Mass.:47502.52
Organism:Homo sapiens (Human)
Description:O14733
Residue:419
Sequence:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50042034
NameBDBM50042034
Synonyms:(5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 | CHEMBL1077979
TypeSmall organic molecule
Emp. Form.C19H22O7
Mol. Mass.362.3738
SMILESCOc1cc(O)c2c(c1)\C=C\C[C@H](O)[C@H](O)C(=O)\C=C/C[C@H](C)OC2=O |r,c:19,t:10|
Structure
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