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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50043655
Substrate
n/a
Meas. Tech.
ChEMBL_1445160 (CHEMBL3374860)
IC50
24±n/a nM
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Foulks, JM; Clifford, A; Lai, S; Chan, A; Merx, S; McCullar, MV; Kanner, SB; Ho, KK Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors. ACS Med Chem Lett 6:63-7 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50043655
Synonyms:
CHEMBL3355557 | US10047093, 8-95 | US10392392, Example 8-95 | US10875864, EX. 8-95 | US9416132, 8-95
Type:
Small organic molecule
Emp. Form.:
C18H20ClN5
Mol. Mass.:
341.838
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1 |r,wU:1.0,wD:4.7,(2.13,-40.45,;3.47,-41.22,;4.8,-40.46,;6.13,-41.22,;6.13,-42.77,;4.8,-43.54,;3.46,-42.76,;7.46,-43.54,;8.79,-42.77,;8.79,-41.23,;10.12,-40.45,;11.45,-41.23,;12.92,-40.75,;13.82,-42,;12.92,-43.24,;13.67,-44.57,;12.89,-45.9,;13.64,-47.24,;15.18,-47.26,;15.97,-45.92,;17.51,-45.93,;15.21,-44.59,;11.45,-42.77,;10.12,-43.53,)|
Structure:
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