Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50043656
Substrate
n/a
Meas. Tech.
ChEMBL_1445160 (CHEMBL3374860)
IC50
111±n/a nM
Citation
 Xu, YBrenning, BGKultgen, SGFoulks, JMClifford, ALai, SChan, AMerx, SMcCullar, MVKanner, SBHo, KK Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors. ACS Med Chem Lett 6:63-7 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50043656
Synonyms:
CHEMBL3355555 | US10047093, 8-59 | US10392392, Example 8-59 | US10875864, EX. 8-59 | US9416132, 8-59
Type:
Small organic molecule
Emp. Form.:
C19H19F3N4O2S
Mol. Mass.:
424.44
SMILES:
FC(F)(F)c1cccc(c1)-c1cnn2ccc(NCC3CCS(=O)(=O)CC3)nc12
Structure:
Search PDB for entries with ligand similarity: