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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50018919
Substrate
n/a
Meas. Tech.
ChEMBL_1449146 (CHEMBL3378734)
Kd
8740000±n/a nM
Citation
 Takrouri, K; Chen, T; Papadopoulos, E; Sahoo, R; Kabha, E; Chen, H; Cantel, S; Wagner, G; Halperin, JA; Aktas, BH; Chorev, M Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors. Eur J Med Chem 77:361-77 (2014) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50018919
Synonyms:
CHEMBL254578
Type:
Small organic molecule
Emp. Form.:
C18H12Cl2N4O4S
Mol. Mass.:
451.283
SMILES:
OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(Cl)c(Cl)c1
Structure:
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