Reaction Details Report a problem with these data
Target
Transcription factor Jun
Ligand
BDBM50044582
Substrate
n/a
Meas. Tech.
ChEMBL_1457997 (CHEMBL3367171)
IC50
>10000±n/a nM
Citation
 Ye, N; Ding, Y; Wild, C; Shen, Q; Zhou, J Small molecule inhibitors targeting activator protein 1 (AP-1). J Med Chem 57:6930-48 (2014) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50044582
Synonyms:
CHEMBL3341902
Type:
Small organic molecule
Emp. Form.:
C14H5ClF9N3O
Mol. Mass.:
437.648
SMILES:
FC(F)(F)c1ccc(NC(=O)c2cc(nc(Cl)n2)C(F)(F)F)c(c1)C(F)(F)F
Structure:
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