Reaction Details Report a problem with these data
Target
Transcription factor Jun
Ligand
BDBM50092879
Substrate
n/a
Meas. Tech.
ChEMBL_1457997 (CHEMBL3367171)
IC50
20±n/a nM
Citation
 Ye, N; Ding, Y; Wild, C; Shen, Q; Zhou, J Small molecule inhibitors targeting activator protein 1 (AP-1). J Med Chem 57:6930-48 (2014) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50092879
Synonyms:
2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide | CHEMBL132495
Type:
Small organic molecule
Emp. Form.:
C14H8ClF6N3O
Mol. Mass.:
383.676
SMILES:
Cc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Structure:
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