Reaction Details Report a problem with these data
Target
Double-strand break repair protein MRE11
Ligand
BDBM50044627
Substrate
n/a
Meas. Tech.
ChEMBL_1446573 (CHEMBL3377972)
IC50
66000±n/a nM
Citation
 Huang, F; Mazin, AV Targeting the homologous recombination pathway by small molecule modulators. Bioorg Med Chem Lett 24:3006-13 (2014) [PubMed]  Article 
Target
Name:
Double-strand break repair protein MRE11
Synonyms:
Double-strand break repair protein MRE11A | HNGS1 | HNGS1 | MRE11 | MRE11 homolog 1 | MRE11 homolog A | MRE11A | MRE11_HUMAN | Meiotic recombination 11 homolog 1 | Meiotic recombination 11 homolog A
Type:
PROTEIN
Mol. Mass.:
80583.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109117
Residue:
708
Sequence:
MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR
  
Inhibitor
Name:
BDBM50044627
Synonyms:
Mirin
Type:
Small organic molecule
Emp. Form.:
C10H8N2O2S
Mol. Mass.:
220.248
SMILES:
Oc1ccc(cc1)-c1cc(=O)[nH]c(=S)[nH]1
Structure:
Search PDB for entries with ligand similarity: