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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50045047
Substrate
n/a
Meas. Tech.
ChEMBL_1453574 (CHEMBL3363159)
IC50
1200±n/a nM
Citation
 Yu, LF; Zhang, HK; Caldarone, BJ; Eaton, JB; Lukas, RJ; Kozikowski, AP Recent developments in novel antidepressants targetinga4ß2-nicotinic acetylcholine receptors. J Med Chem 57:8204-23 (2014) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50045047
Synonyms:
Dexmecamylamine | TC-5214
Type:
Small organic molecule
Emp. Form.:
C11H21N
Mol. Mass.:
167.2911
SMILES:
[H][C@]12CC[C@]([H])(C1)[C@](C)(NC)C2(C)C |r|
Structure:
Search PDB for entries with ligand similarity: