Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 4
Ligand
BDBM50045205
Substrate
n/a
Meas. Tech.
ChEMBL_1458079 (CHEMBL3367642)
IC50
603±n/a nM
Citation
 Miah, AH; Abas, H; Begg, M; Marsh, BJ; O'Flynn, DE; Ford, AJ; Percy, JM; Procopiou, PA; Richards, SA; Rumley, SA Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists. Bioorg Med Chem 22:4298-311 (2014) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50045205
Synonyms:
CHEMBL3310825
Type:
Small organic molecule
Emp. Form.:
C15H13Cl2N3O3S
Mol. Mass.:
386.253
SMILES:
COc1cccc2n(C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12
Structure:
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