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Target
Similar to alpha-tubulin isoform 1
Ligand
BDBM50014846
Substrate
n/a
Meas. Tech.
ChEMBL_1447531 (CHEMBL3373138)
IC50
1340±n/a nM
Citation
 Yin, Y; Qiao, F; Jiang, LY; Wang, SF; Sha, S; Wu, X; Lv, PC; Zhu, HL Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors. Bioorg Med Chem 22:4285-92 (2014) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Similar to alpha-tubulin isoform 1
Type:
PROTEIN
Mol. Mass.:
10383.05
Organism:
Bos taurus
Description:
ChEMBL_104716
Residue:
99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
  
Inhibitor
Name:
BDBM50014846
Synonyms:
(S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide | (S)-colchicine | 7alphaH-colchicine | CHEMBL107 | COLCHICINE | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide | colchicina | colchicinum
Type:
Small organic molecule
Emp. Form.:
C22H25NO6
Mol. Mass.:
399.437
SMILES:
COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC |r|
Structure:
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