Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50046430
Substrate
n/a
Meas. Tech.
ChEMBL_1449322 (CHEMBL3371468)
Ki
0.110000±n/a nM
Citation
 Orwat, MJ; Qiao, JX; He, K; Rendina, AR; Luettgen, JM; Rossi, KA; Xin, B; Knabb, RM; Wexler, RR; Lam, PY; Pinto, DJ Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties. Bioorg Med Chem Lett 24:3341-5 (2014) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50046430
Synonyms:
CHEMBL3314442
Type:
Small organic molecule
Emp. Form.:
C26H32N4O4S
Mol. Mass.:
496.622
SMILES:
COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)C(C)(C)CN(C)C)S(C)(=O)=O
Structure:
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