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Target
Protein phosphatase 1D
Ligand
BDBM50046672
Substrate
n/a
Meas. Tech.
ChEMBL_1451879 (CHEMBL3362813)
IC50
<20000±n/a nM
Citation
 Cheeseman, MD; Faisal, A; Rayter, S; Barbeau, OR; Kalusa, A; Westlake, M; Burke, R; Swan, M; van Montfort, R; Linardopoulos, S; Jones, K Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorg Med Chem Lett 24:3469-74 (2014) [PubMed]  Article 
Target
Name:
Protein phosphatase 1D
Synonyms:
PP2C-delta | PPM1D | PPM1D_HUMAN | Protein phosphatase 2C isoform delta | Protein phosphatase magnesium-dependent 1 delta | WIP1 | p53-induced protein phosphatase 1
Type:
PROTEIN
Mol. Mass.:
66695.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515094
Residue:
605
Sequence:
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC
  
Inhibitor
Name:
BDBM50046672
Synonyms:
CHEMBL3314471
Type:
Small organic molecule
Emp. Form.:
C18H13FN2OS
Mol. Mass.:
324.372
SMILES:
Cc1cc(F)ccc1-c1nc(cs1)-c1ccc2NC(=O)Cc2c1
Structure:
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