Target
Protein phosphatase 1D
Ligand
BDBM50046675
Substrate
n/a
Meas. Tech.
ChEMBL_1451879 (CHEMBL3362813)
IC50
<20000±n/a nM
Citation
 Cheeseman, MDFaisal, ARayter, SBarbeau, ORKalusa, AWestlake, MBurke, RSwan, Mvan Montfort, RLinardopoulos, SJones, K Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines. Bioorg Med Chem Lett 24:3469-74 (2014) [PubMed]  Article 
Target
Name:
Protein phosphatase 1D
Synonyms:
PP2C-delta | PPM1D | PPM1D_HUMAN | Protein phosphatase 2C isoform delta | Protein phosphatase magnesium-dependent 1 delta | WIP1 | p53-induced protein phosphatase 1
Type:
PROTEIN
Mol. Mass.:
66695.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515094
Residue:
605
Sequence:
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC
  
Inhibitor
Name:
BDBM50046675
Synonyms:
CHEMBL3314474
Type:
Small organic molecule
Emp. Form.:
C21H21FN4OS
Mol. Mass.:
396.481
SMILES:
CN(C)CCn1c2ccc(cc2[nH]c1=O)-c1csc(n1)-c1ccc(F)cc1C
Structure:
Search PDB for entries with ligand similarity: