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TargetUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
LigandBDBM50046822
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1452800
IC50 330000±n/a nM
Citation Perdih, AHrast, MBarreteau, HGobec, SWolber, GSolmajer, T Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF). Bioorg Med Chem22:4124-34 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
Name:UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
Synonyms:JW0083 | Meso-A2pm-adding enzyme | Meso-diaminopimelate-adding enzyme | UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase | UDP-MurNAc-tripeptide synthetase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase | UDP-N-acetylmuramyl-tripeptide synthetase | murE
Type:PROTEIN
Mol. Mass.:53333.42
Organism:Escherichia coli (strain K12)
Description:ChEMBL_109170
Residue:495
Sequence:
MADRNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGV
AAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGK
TTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFC
AMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIIN
ADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIE
SHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAH
TPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEE
PRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLD
YSDRVTVARLLGVIA
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  Blast E-value cutoff:
BDBM50046822
n/a
NameBDBM50046822
Synonyms:CHEMBL3310456
TypeSmall organic molecule
Emp. Form.C27H23N3O7
Mol. Mass.501.4874
SMILESCCc1ccc(cc1)N1C(=O)NC(=O)\C(=C\c2cc(C)n(c2C)-c2cc(cc(c2)C(O)=O)C(O)=O)C1=O
Structure
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