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Target
Polymerase basic protein 2
Ligand
BDBM50050713
Substrate
n/a
Meas. Tech.
ChEMBL_1458393 (CHEMBL3369823)
Kd
500±n/a nM
Citation
 Clark, MP; Ledeboer, MW; Davies, I; Byrn, RA; Jones, SM; Perola, E; Tsai, A; Jacobs, M; Nti-Addae, K; Bandarage, UK; Boyd, MJ; Bethiel, RS; Court, JJ; Deng, H; Duffy, JP; Dorsch, WA; Farmer, LJ; Gao, H; Gu, W; Jackson, K; Jacobs, DH; Kennedy, JM; Ledford, B; Liang, J; Maltais, F; Murcko, M; Wang, T; Wannamaker, MW; Bennett, HB; Leeman, JR; McNeil, C; Taylor, WP; Memmott, C; Jiang, M; Rijnbrand, R; Bral, C; Germann, U; Nezami, A; Zhang, Y; Salituro, FG; Bennani, YL; Charifson, PS Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2. J Med Chem 57:6668-78 (2014) [PubMed]  Article 
Target
Name:
Polymerase basic protein 2
Synonyms:
PB2 | PB2_I34A1 | Polymerase basic protein 2 | RNA-directed RNA polymerase subunit P3
Type:
PROTEIN
Mol. Mass.:
86120.80
Organism:
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Description:
ChEMBL_109460
Residue:
759
Sequence:
MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPITNTVHYPKIYKTYFERVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGVEPIDNVMGMIGILPDMTPSIEMSMRGVRISKMGVDEYSSTERVVVSIDRFLRIRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTAQIIKLLPFAAAPPKQSRMQFSSFTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGTLTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
  
Inhibitor
Name:
BDBM50050713
Synonyms:
CHEMBL3317987
Type:
Small organic molecule
Emp. Form.:
C22H25ClFN7O2
Mol. Mass.:
473.931
SMILES:
Fc1cnc(nc1N[C@H]1CCC[C@H](C1)NC(=O)N1CCOCC1)-c1c[nH]c2ncc(Cl)cc12 |r|
Structure:
Search PDB for entries with ligand similarity: