Reaction Details Report a problem with these data
Target
Glutathione S-transferase A1
Ligand
BDBM50054198
Substrate
n/a
Meas. Tech.
ChEMBL_1458318 (CHEMBL3369280)
Ki
360±n/a nM
Citation
 Perperopoulou, FD; Tsoungas, PG; Thireou, TN; Rinotas, VE; Douni, EK; Eliopoulos, EE; Labrou, NE; Clonis, YD 2,2'-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1. Bioorg Med Chem 22:3957-70 (2014) [PubMed]  Article 
Target
Name:
Glutathione S-transferase A1
Synonyms:
GST class-alpha member 1 | GST-epsilon | GSTA1 | GSTA1-1 | GSTA1_HUMAN | GTH1 | Glutathione S-transferase (GST) | HA subunit 1
Type:
Enzyme
Mol. Mass.:
25636.31
Organism:
Homo sapiens (Human)
Description:
Glutathione-S-Transferase (GST, N-terminally)
Residue:
222
Sequence:
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
  
Inhibitor
Name:
BDBM50054198
Synonyms:
CHEMBL3310888
Type:
Small organic molecule
Emp. Form.:
C13H9BrO3
Mol. Mass.:
293.113
SMILES:
Oc1ccccc1C(=O)c1cc(Br)ccc1O
Structure:
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