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Target
Dual specificity protein phosphatase 23
Ligand
BDBM50054344
Substrate
n/a
Meas. Tech.
ChEMBL_1458328 (CHEMBL3369290)
IC50
2300±n/a nM
Citation
 Zeng, LF; Zhang, RY; Yu, ZH; Li, S; Wu, L; Gunawan, AM; Lane, BS; Mali, RS; Li, X; Chan, RJ; Kapur, R; Wells, CD; Zhang, ZY Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem 57:6594-609 (2014) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 23
Synonyms:
DUS23_HUMAN | DUSP23 | Dual specificity protein phosphatase 23 | Dual specificity protein phosphatase 23 (VHZ) | LDP-3 | LDP3 | Low molecular mass dual specificity phosphatase 3 | VH1-like phosphatase Z | VHZ
Type:
Enzyme
Mol. Mass.:
16592.49
Organism:
Homo sapiens (Human)
Description:
Q9BVJ7
Residue:
150
Sequence:
MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHSDSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRTGTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK
  
Inhibitor
Name:
BDBM50054344
Synonyms:
CHEMBL3319356 | US9522881, 11a-1 L97M74 | US9844535, ID 11a-1 L97M74
Type:
Small organic molecule
Emp. Form.:
C28H20IN3O5S
Mol. Mass.:
637.445
SMILES:
Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1
Structure:
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