Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM170456
Substrate
n/a
Meas. Tech.
ChEMBL_1450415 (CHEMBL3379359)
IC50
8.8±n/a nM
Citation
 Liu, SZha, CNacro, KHu, MCui, WYang, YLBhatt, USambandam, AIsherwood, MYet, LHerr, MTEbeltoft, SHassler, CFleming, LPechulis, ADPayen-Fornicola, AHolman, NMilanowski, DCotterill, IMozhaev, VKhmelnitsky, YGuzzo, PRSargent, BJMolino, BFOlson, RKing, DLelas, SLi, YWJohnson, KMolski, TOrie, ANg, AHaskell, RClarke, WBertekap, RO'Connell, JLodge, NSinz, MAdams, SZaczek, RMacor, JE Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors. ACS Med Chem Lett 5:760-5 (2014) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM170456
Synonyms:
US9085531, 119
Type:
Small organic molecule
Emp. Form.:
C18H18N2
Mol. Mass.:
262.3489
SMILES:
CN1CC(c2ccc3cc[nH]c3c2)c2ccccc2C1
Structure:
Search PDB for entries with ligand similarity: