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Target
D(4) dopamine receptor
Ligand
BDBM21398
Substrate
n/a
Meas. Tech.
ChEMBL_1452246 (CHEMBL3366158)
Ki
10.0±n/a nM
Citation
 Sampson, D; Bricker, B; Zhu, XY; Peprah, K; Lamango, NS; Setola, V; Roth, BL; Ablordeppey, SY Further evaluation of the tropane analogs of haloperidol. Bioorg Med Chem Lett 24:4294-7 (2014) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(4) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.4 | DRD4_RAT | Dopamine receptor | Drd4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41307.65
Organism:
RAT
Description:
DOPAMINE D4.4 0 RAT::P30729
Residue:
387
Sequence:
MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
  
Inhibitor
Name:
BDBM21398
Synonyms:
4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) | 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one | CHEMBL54 | CHEMBL545608 | Haloperidol | Haloperidol, 1
Type:
Small organic molecule
Emp. Form.:
C21H23ClFNO2
Mol. Mass.:
375.864
SMILES:
OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: