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Target
P2Y purinoceptor 12
Ligand
BDBM50055820
Substrate
n/a
Meas. Tech.
ChEMBL_1454020 (CHEMBL3367079)
IC50
400±n/a nM
Citation
 Boldron, C; Besse, A; Bordes, MF; Tissandié, S; Yvon, X; Gau, B; Badorc, A; Rousseaux, T; Barré, G; Meneyrol, J; Zech, G; Nazare, M; Fossey, V; Pflieger, AM; Bonnet-Lignon, S; Millet, L; Briot, C; Dol, F; Hérault, JP; Savi, P; Lassalle, G; Delesque, N; Herbert, JM; Bono, F N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J Med Chem 57:7293-316 (2014) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 12
Synonyms:
P2Y purinoceptor 12 | P2Y12_RAT | P2ry12 | P2y12 | Purinergic receptor P2Y12
Type:
PROTEIN
Mol. Mass.:
39068.50
Organism:
Rattus norvegicus
Description:
ChEMBL_1454020
Residue:
343
Sequence:
MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM
  
Inhibitor
Name:
BDBM50055820
Synonyms:
CHEMBL3325664
Type:
Small organic molecule
Emp. Form.:
C33H40N6O3
Mol. Mass.:
568.7091
SMILES:
CCCC(=O)c1cnn(c1C)-c1ccc(NC(=O)c2cn(CC(=O)N3CCN(CC3)C(C)C)c3ccc(C)cc23)cc1
Structure:
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