Reaction Details Report a problem with these data
Target
Dynamin-2
Ligand
BDBM50055862
Substrate
n/a
Meas. Tech.
ChEMBL_1458574 (CHEMBL3370892)
IC50
43700±n/a nM
Citation
 MacGregor, KA; Abdel-Hamid, MK; Odell, LR; Chau, N; Whiting, A; Robinson, PJ; McCluskey, A Development of quinone analogues as dynamin GTPase inhibitors. Eur J Med Chem 85:191-206 (2014) [PubMed]  Article 
Target
Name:
Dynamin-2
Synonyms:
DYN2_RAT | Dnm2 | Dyn2
Type:
PROTEIN
Mol. Mass.:
98236.76
Organism:
Rattus norvegicus
Description:
ChEMBL_1458574
Residue:
870
Sequence:
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEYAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGRKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELISTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESAEQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQNTSSHSPTPQRRPVSSVHPPGRPPAVRGPTPGPPLIPMPVGATSSFSAPPIPSRPGPQNVFANNDPFSAPPQIPSRPARIPPGIPPGVPSRRAPAAPSRPTIIRPAEPSLLD
  
Inhibitor
Name:
BDBM50055862
Synonyms:
CHEMBL3329969
Type:
Small organic molecule
Emp. Form.:
C18H14N2O4
Mol. Mass.:
322.3148
SMILES:
Oc1cccc(NC2=CC(=O)C(Nc3cccc(O)c3)=CC2=O)c1 |c:20,t:7|
Structure:
Search PDB for entries with ligand similarity: