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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50056009
Substrate
n/a
Meas. Tech.
ChEMBL_1447044 (CHEMBL3374950)
EC50
41±n/a nM
Citation
 Buzard, DJ; Kim, SH; Lehmann, J; Han, S; Calderon, I; Wong, A; Kawasaki, A; Narayanan, S; Bhat, R; Gharbaoui, T; Lopez, L; Yue, D; Whelan, K; Al-Shamma, H; Unett, DJ; Shu, HH; Tung, SF; Chang, S; Chuang, CF; Morgan, M; Sadeque, A; Chu, ZL; Leonard, JN; Jones, RM Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett 24:4332-5 (2014) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_RAT | Gpr119
Type:
PROTEIN
Mol. Mass.:
51687.59
Organism:
Rattus norvegicus
Description:
ChEMBL_1506411
Residue:
468
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
  
Inhibitor
Name:
BDBM50056009
Synonyms:
CHEMBL3326672
Type:
Small organic molecule
Emp. Form.:
C20H25FN4O5S2
Mol. Mass.:
484.565
SMILES:
CC(C)SC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Structure:
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