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Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50056450
Substrate
n/a
Meas. Tech.
ChEMBL_1452286 (CHEMBL3366540)
EC50
>50000±n/a nM
Citation
Santella, JB; Gardner, DS; Duncia, JV; Wu, H; Dhar, M; Cavallaro, C; Tebben, AJ; Carter, PH; Barrish, JC; Yarde, M; Briceno, SW; Cvijic, ME; Grafstrom, RR; Liu, R; Patel, SR; Watson, AJ; Yang, G; Rose, AV; Vickery, RD; Caceres-Cortes, J; Caporuscio, C; Camac, DM; Khan, JA; An, Y; Foster, WR; Davies, P; Hynes, J Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J Med Chem 57:7550-64 (2014) [PubMed] Article
More Info.:
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS