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Target
Tubulin beta chain
Ligand
BDBM50056794
Substrate
n/a
Meas. Tech.
ChEMBL_1455831 (CHEMBL3361924)
IC50
4800±n/a nM
Citation
 Solum, EJ; Cheng, JJ; Sørvik, IB; Paulsen, RE; Vik, A; Hansen, TV Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: inhibitors of tubulin and angiogenesis. Eur J Med Chem 85:391-8 (2014) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50056794
Synonyms:
CHEMBL3331349
Type:
Small organic molecule
Emp. Form.:
C28H29NO2
Mol. Mass.:
411.5354
SMILES:
[H][C@@]12CC=C(c3cncc4ccccc34)[C@@]1(C)CC[C@]1([H])c3cc(OC)c(O)cc3CC[C@@]21[H] |r,t:3|
Structure:
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