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Target
Glucagon receptor
Ligand
BDBM50057824
Substrate
n/a
Meas. Tech.
ChEMBL_1450588 (CHEMBL3372166)
IC50
87±n/a nM
Citation
 Hasegawa, F; Niidome, K; Migihashi, C; Murata, M; Negoro, T; Matsumoto, T; Kato, K; Fujii, A Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists. Bioorg Med Chem Lett 24:4266-70 (2014) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GL-R | GLR_RAT | Gcgr
Type:
PROTEIN
Mol. Mass.:
55053.40
Organism:
Rattus norvegicus
Description:
ChEMBL_1450588
Residue:
485
Sequence:
MLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
  
Inhibitor
Name:
BDBM50057824
Synonyms:
CHEMBL3326175
Type:
Small organic molecule
Emp. Form.:
C24H17N3O6
Mol. Mass.:
443.4083
SMILES:
Oc1ccc(cc1[N+]([O-])=O)C(=O)NNC(=O)c1occ(c1-c1ccccc1)-c1ccccc1
Structure:
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