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Target
DNA topoisomerase 4 subunit B
Ligand
BDBM50058511
Substrate
n/a
Meas. Tech.
ChEMBL_1448970 (CHEMBL3376317)
IC50
780±n/a nM
Citation
 Yule, IA; Czaplewski, LG; Pommier, S; Davies, DT; Narramore, SK; Fishwick, CW Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity. Eur J Med Chem 86:31-8 (2014) [PubMed]  Article 
Target
Name:
DNA topoisomerase 4 subunit B
Synonyms:
DNA Topoisomerase IV Subunit B | DNA topoisomerase 4 subunit B (parE) | PARE_ECOLI | nfxD | parE
Type:
Enzyme Subunit
Mol. Mass.:
70233.03
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
630
Sequence:
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVNALSKRVEVNVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFSVSRLTHVLKAKAVLCPGVEITFKDEINNTEQRWCYQDGLNDYLAEAVNGLPTLPEKPFIGNFAGDTEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNILPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFILWLNQNVQAAELLAEMAISSAQRRMRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHIATLLCALFVKHFRALVKHGHVYVALPPLYRIDLGKEVYYALTEEEKEGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTIDDEDDQRTDAMMDMLLAKKRSEDRRNWLQEKGDMAEIEV
  
Inhibitor
Name:
BDBM50058511
Synonyms:
CHEMBL3329318
Type:
Small organic molecule
Emp. Form.:
C20H20N6O3
Mol. Mass.:
392.4112
SMILES:
CCNC(=O)Nc1cc(Nc2cccc(O)c2)c(cn1)C(=O)Nc1cccnc1
Structure:
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