Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50058707
Substrate
n/a
Meas. Tech.
ChEMBL_1448997 (CHEMBL3376894)
IC50
6000±n/a nM
Citation
Al-Rashood, ST; Hassan, GS; El-Messery, SM; Nagi, MN; Habib, el-SE; Al-Omary, FA; El-Subbagh, HI Synthesis, biological evaluation and molecular modeling study of 2-(1,3,4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors. Bioorg Med Chem Lett 24:4557-67 (2014) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:
Enzyme
Mol. Mass.:
21603.71
Organism:
Bos taurus (Cattle)
Description:
P00376
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSSVYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKFEVYEKNN