Target
Dihydrofolate reductase
Ligand
BDBM50058707
Substrate
n/a
Meas. Tech.
ChEMBL_1448997 (CHEMBL3376894)
IC50
6000±n/a nM
Citation
 Al-Rashood, STHassan, GSEl-Messery, SMNagi, MNHabib, el-SEAl-Omary, FAEl-Subbagh, HI Synthesis, biological evaluation and molecular modeling study of 2-(1,3,4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors. Bioorg Med Chem Lett 24:4557-67 (2014) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:
Enzyme
Mol. Mass.:
21603.71
Organism:
Bos taurus (Cattle)
Description:
P00376
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSSVYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKFEVYEKNN
  
Inhibitor
Name:
BDBM50058707
Synonyms:
CHEMBL3326814
Type:
Small organic molecule
Emp. Form.:
C16H10ClN5OS2
Mol. Mass.:
387.867
SMILES:
Nc1nnc(Sc2nc3ccc(Cl)cc3c(=O)n2-c2ccccc2)s1
Structure:
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