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TargetInosine-5'-monophosphate dehydrogenase
LigandBDBM50432791
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1452432
Ki 24±n/a nM
Citation Mandapati, KGorla, SKHouse, ALMcKenney, ESZhang, MRao, SNGollapalli, DRMann, BJGoldberg, JBCuny, GDGlomski, IJHedstrom, L Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. ACS Med Chem Lett5:846-50 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Inosine-5'-monophosphate dehydrogenase
Name:Inosine-5'-monophosphate dehydrogenase
Synonyms:AB164_07585 | AB165_01610 | AB166_11280 | AB167_18060 | AB168_06335 | AB169_08740 | AB170_00090 | AB171_19425 | AB893_00065 | ABW01_29210 | ADT20_14595 | ADT21_00085 | BF27_2004 | Inosine-5''-monophosphate dehydrogenase | guaB
Type:PROTEIN
Mol. Mass.:52375.32
Organism:Bacillus anthracis
Description:ChEMBL_109471
Residue:487
Sequence:
MWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLISAGMDTVTEADMA
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRI
SGVPVVNNLDERKLVGIITNRDMRFIQDYSIKISDVMTKEQLITAPVGTTLSEAEKILQK
YKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDAL
VKASVDAIVLDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATKALIEAGANVVKV
GIGPGSICTTRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHV
VMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEGNKKLVPEGIEG
RVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFIRMSGAGLLESHPHHVQITK
EAPNYSL
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  Blast E-value cutoff:
BDBM50432791
NameBDBM50432791
Synonyms:CHEMBL2348823
TypeSmall organic molecule
Emp. Form.C25H19N3O3
Mol. Mass.409.4367
SMILESC[C@H](Oc1cccc2ccccc12)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r|
Structure
n/a