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TargetInosine-5'-monophosphate dehydrogenase
LigandBDBM50100896
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1452429
IC50 760±n/a nM
Citation Mandapati, KGorla, SKHouse, ALMcKenney, ESZhang, MRao, SNGollapalli, DRMann, BJGoldberg, JBCuny, GDGlomski, IJHedstrom, L Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. ACS Med Chem Lett5:846-50 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Inosine-5'-monophosphate dehydrogenase
Name:Inosine-5'-monophosphate dehydrogenase
Synonyms:AB164_07585 | AB165_01610 | AB166_11280 | AB167_18060 | AB168_06335 | AB169_08740 | AB170_00090 | AB171_19425 | AB893_00065 | ABW01_29210 | ADT20_14595 | ADT21_00085 | BF27_2004 | Inosine-5''-monophosphate dehydrogenase | guaB
Type:PROTEIN
Mol. Mass.:52375.32
Organism:Bacillus anthracis
Description:ChEMBL_109471
Residue:487
Sequence:
MWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPLISAGMDTVTEADMA
IAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVISDPFFLTPEHQVYDAEHLMGKYRI
SGVPVVNNLDERKLVGIITNRDMRFIQDYSIKISDVMTKEQLITAPVGTTLSEAEKILQK
YKIEKLPLVDNNGVLQGLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDAL
VKASVDAIVLDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATKALIEAGANVVKV
GIGPGSICTTRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKYSGDMVKALAAGAHV
VMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGAMEKGSKDRYFQEGNKKLVPEGIEG
RVPYKGPLADTVHQLVGGLRAGMGYCGAQDLEFLRENAQFIRMSGAGLLESHPHHVQITK
EAPNYSL
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  Blast E-value cutoff:
BDBM50100896
NameBDBM50100896
Synonyms:CHEMBL3329560
TypeSmall organic molecule
Emp. Form.C18H14BrNO2
Mol. Mass.356.213
SMILESBrc1ccc(NC(=O)COc2cccc3ccccc23)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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