Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase 26
Ligand
BDBM50059277
Substrate
n/a
Meas. Tech.
ChEMBL_1460603 (CHEMBL3395733)
IC50
178±n/a nM
Citation
 Henderson, JL; Kormos, BL; Hayward, MM; Coffman, KJ; Jasti, J; Kurumbail, RG; Wager, TT; Verhoest, PR; Noell, GS; Chen, Y; Needle, E; Berger, Z; Steyn, SJ; Houle, C; Hirst, WD; Galatsis, P Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem 58:419-32 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 26
Synonyms:
MASK | MST4 | STK26 | STK26_HUMAN | Serine/threonine-protein kinase MST4
Type:
PROTEIN
Mol. Mass.:
46517.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510631
Residue:
416
Sequence:
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
  
Inhibitor
Name:
BDBM50059277
Synonyms:
CHEMBL3393348 | US9156845, 4
Type:
Small organic molecule
Emp. Form.:
C17H15N5O
Mol. Mass.:
305.3339
SMILES:
N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Structure:
Search PDB for entries with ligand similarity: