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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50061168
Substrate
n/a
Meas. Tech.
ChEMBL_1461408 (CHEMBL3396421)
IC50
0.400000±n/a nM
Citation
 Wang, HL; Cee, VJ; Chavez, F; Lanman, BA; Reed, AB; Wu, B; Guerrero, N; Lipford, JR; Sastri, C; Winston, J; Andrews, KL; Huang, X; Lee, MR; Mohr, C; Xu, Y; Zhou, Y; Tasker, AS The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. Bioorg Med Chem Lett 25:834-40 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50061168
Synonyms:
CHEMBL3393706
Type:
Small organic molecule
Emp. Form.:
C24H21F2N5O
Mol. Mass.:
433.4532
SMILES:
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC44CC4)n3)c2c1 |r|
Structure:
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