Reaction Details Report a problem with these data
Target
Solute carrier family 40 member 1
Ligand
BDBM50061367
Substrate
n/a
Meas. Tech.
ChEMBL_1461557 (CHEMBL3396798)
EC50
6.3±n/a nM
Citation
 Fung, E; Chua, K; Ganz, T; Nemeth, E; Ruchala, P Thiol-derivatized minihepcidins retain biological activity. Bioorg Med Chem Lett 25:763-6 (2015) [PubMed]  Article 
Target
Name:
Solute carrier family 40 member 1
Synonyms:
FPN | FPN1 | FPN1 | Ferroportin-1 | IREG1 | Iron-regulated transporter 1 | S40A1_HUMAN | SLC11A3 | SLC40A1 | Solute carrier family 40 member 1
Type:
PROTEIN
Mol. Mass.:
62541.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109560
Residue:
571
Sequence:
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
  
Inhibitor
Name:
BDBM50061367
Synonyms:
CHEMBL3393871
Type:
Small organic molecule
Emp. Form.:
C97H149N21O19S
Mol. Mass.:
1945.415
SMILES:
CCCCCCCCCCCCCCCCNC(=O)CN(CC(N)=O)C(=O)CCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS\C(=C/C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)CNC(=O)CO)[C@@H](C)O)C(c1ccccc1)c1ccccc1 |r|
Structure:
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