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Target
Delta-type opioid receptor
Ligand
BDBM50061374
Substrate
n/a
Meas. Tech.
ChEMBL_1461562 (CHEMBL3396803)
EC50
5200±n/a nM
Citation
 Sasmal, PK; Krishna, CV; Adabala, SS; Roshaiah, M; Rawoof, KA; Thadi, E; Sukumar, KP; Cheera, S; Abbineni, C; Rao, KV; Prasanthi, A; Nijhawan, K; Jaleel, M; Iyer, LR; Chaitanya, TK; Tiwari, NK; Krishna, NL; Potluri, V; Khanna, I; Frimurer, TM; Lückmann, M; Rist, Ø; Elster, L; Högberg, T Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists. Bioorg Med Chem Lett 25:887-92 (2015) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50061374
Synonyms:
CHEMBL3393998
Type:
Small organic molecule
Emp. Form.:
C22H22N4OS
Mol. Mass.:
390.501
SMILES:
O=C(Nc1nc2ccccc2n1CCN1CCCC1)c1cc2ccccc2s1
Structure:
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