Target
Renin
Ligand
BDBM50065425
Substrate
n/a
Meas. Tech.
ChEMBL_1465911 (CHEMBL3406559)
Ki
15±n/a nM
Citation
 McKittrick, BACaldwell, JPBara, TBoykow, GChintala, MClader, JCzarniecki, MCourneya, BDuffy, RFleming, LGiessert, RGreenlee, WJHeap, CHong, LHuang, YIserloh, UJosien, HKhan, TKorfmacher, WLiang, XMazzola, RMitra, SMoore, KOrth, PRajagopalan, MRoy, SSakwa, SStrickland, CVaccaro, HVoigt, JWang, HWong, JZhang, RZych, A Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors. Bioorg Med Chem Lett 25:1592-6 (2015) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50065425
Synonyms:
CHEMBL3401347
Type:
Small organic molecule
Emp. Form.:
C24H31N5O
Mol. Mass.:
405.5358
SMILES:
CC(C)[C@]1(C)CC(=O)N(Cc2ccnc(c2)N2CC[C@@H](C2)c2ccccc2)C(=N)N1 |r|
Structure:
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