Target
Cathepsin E
Ligand
BDBM50065660
Substrate
n/a
Meas. Tech.
ChEMBL_1464648 (CHEMBL3406669)
IC50
>30000±n/a nM
Citation
 Sellner, HCottens, SCumin, FEhrhardt, CKosaka, TLorthiois, EOstermann, NWebb, RLRigel, DFWagner, TMaibaum, J trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker. Bioorg Med Chem Lett 25:1787-91 (2015) [PubMed]  Article 
Target
Name:
Cathepsin E
Synonyms:
3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II
Type:
Enzyme
Mol. Mass.:
43298.99
Organism:
Homo sapiens (Human)
Description:
P14091
Residue:
396
Sequence:
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
  
Inhibitor
Name:
BDBM50065660
Synonyms:
CHEMBL3403995
Type:
Small organic molecule
Emp. Form.:
C28H39N3O6
Mol. Mass.:
513.6258
SMILES:
COCCCOc1cc(ccc1OC)C(=O)N(C[C@@H]1CNC[C@H]1OC(=O)NCc1ccccc1)C(C)C |r|
Structure:
Search PDB for entries with ligand similarity: