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Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM29590
Substrate
n/a
Meas. Tech.
ChEMBL_1465148 (CHEMBL3405661)
IC50
>100000±n/a nM
Citation
 Li, Y; Huang, W; You, L; Xie, T; He, B A FRET-based assay for screening SIRT5 specific modulators. Bioorg Med Chem Lett 25:1671-4 (2015) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM29590
Synonyms:
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one | CHEMBL86537 | splitomicin
Type:
Small organic molecule
Emp. Form.:
C13H10O2
Mol. Mass.:
198.2173
SMILES:
O=C1CCc2c(O1)ccc1ccccc21
Structure:
Search PDB for entries with ligand similarity: