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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM144636
Substrate
n/a
Meas. Tech.
ChEMBL_1469499 (CHEMBL3412296)
IC50
0.100000±n/a nM
Citation
 Rew, Y; Sun, D; Yan, X; Beck, HP; Canon, J; Chen, A; Duquette, J; Eksterowicz, J; Fox, BM; Fu, J; Gonzalez, AZ; Houze, J; Huang, X; Jiang, M; Jin, L; Li, Y; Li, Z; Ling, Y; Lo, MC; Long, AM; McGee, LR; McIntosh, J; Oliner, JD; Osgood, T; Saiki, AY; Shaffer, P; Wang, YC; Wortman, S; Yakowec, P; Ye, Q; Yu, D; Zhao, X; Zhou, J; Medina, JC; Olson, SH Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. J Med Chem 57:10499-511 (2014) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM144636
Synonyms:
US8952036, Ex. 4
Type:
Small organic molecule
Emp. Form.:
C29H34Cl2FNO5S
Mol. Mass.:
598.553
SMILES:
CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)c(F)c1 |r|
Structure:
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