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Target
Pteridine reductase 1
Ligand
BDBM50071579
Substrate
n/a
Meas. Tech.
ChEMBL_1470027 (CHEMBL3412013)
Kd
93±n/a nM
Citation
 Mendoza-Martínez, C; Galindo-Sevilla, N; Correa-Basurto, J; Ugalde-Saldivar, VM; Rodríguez-Delgado, RG; Hernández-Pineda, J; Padierna-Mota, C; Flores-Alamo, M; Hernández-Luis, F Antileishmanial activity of quinazoline derivatives: synthesis, docking screens, molecular dynamic simulations and electrochemical studies. Eur J Med Chem 92:314-31 (2015) [PubMed]  Article 
Target
Name:
Pteridine reductase 1
Synonyms:
HMTXR | PTR1 | PTR1_LEIMA
Type:
PROTEIN
Mol. Mass.:
30459.34
Organism:
Leishmania major
Description:
ChEMBL_1470027
Residue:
288
Sequence:
MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
  
Inhibitor
Name:
BDBM50071579
Synonyms:
CHEMBL3410464
Type:
Small organic molecule
Emp. Form.:
C18H14Cl2F3N7
Mol. Mass.:
456.252
SMILES:
Nc1nc(N)c2cc(NCCn3c(nc4cc(Cl)c(Cl)cc34)C(F)(F)F)ccc2n1
Structure:
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