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TargetDihydroorotate dehydrogenase
LigandBDBM50071622
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1470241
IC50 35±n/a nM
Citation Zhu, JHan, LDiao, YRen, XXu, MXu, LLi, SLi, QDong, DHuang, JLiu, XZhao, ZWang, RZhu, LXu, YQian, XLi, H Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase. J Med Chem58:1123-39 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase
Name:Dihydroorotate dehydrogenase
Synonyms:DHOdehase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH)
Type:Enzyme
Mol. Mass.:42881.33
Organism:Homo sapiens (Human)
Description:Q02127
Residue:395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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  Blast E-value cutoff:
BDBM50071622
NameBDBM50071622
Synonyms:CHEMBL3410596
TypeSmall organic molecule
Emp. Form.C19H17ClN2O2S
Mol. Mass.372.868
SMILESCCOC(=O)c1sc(Nc2ccc(C)c(Cl)c2)nc1-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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