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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50072080
Substrate
n/a
Meas. Tech.
ChEMBL_1467949 (CHEMBL3413306)
IC50
11±n/a nM
Citation
 Toledo-Sherman, LM; Prime, ME; Mrzljak, L; Beconi, MG; Beresford, A; Brookfield, FA; Brown, CJ; Cardaun, I; Courtney, SM; Dijkman, U; Hamelin-Flegg, E; Johnson, PD; Kempf, V; Lyons, K; Matthews, K; Mitchell, WL; O'Connell, C; Pena, P; Powell, K; Rassoulpour, A; Reed, L; Reindl, W; Selvaratnam, S; Friley, WW; Weddell, DA; Went, NE; Wheelan, P; Winkler, C; Winkler, D; Wityak, J; Yarnold, CJ; Yates, D; Munoz-Sanjuan, I; Dominguez, C Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease. J Med Chem 58:1159-83 (2015) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO_MOUSE | Kmo | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase
Type:
PROTEIN
Mol. Mass.:
54550.12
Organism:
Mus musculus
Description:
ChEMBL_109577
Residue:
479
Sequence:
MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSYRGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISRENLNKDLLTAVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKKPRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMPFEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSHCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNNLSMCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLIAIGGTYLLVHHLSLRPLEFLRRPAWMGTTGYWTRSTDISLQVPWSY
  
Inhibitor
Name:
BDBM50072080
Synonyms:
CHEMBL3407919
Type:
Small organic molecule
Emp. Form.:
C12H6ClF3N2O3
Mol. Mass.:
318.636
SMILES:
OC(=O)c1cc(ncn1)-c1ccc(OC(F)(F)F)c(Cl)c1
Structure:
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